Research & Discovery
Our work sits at the intersection of synthesis and biology. Each project below is open to students — whether you are exploring research for the first time or planning a doctoral thesis.
Bioorganic chemistry
We design and synthesise small molecules that engage chromatin-binding proteins with precision. Structure-guided design, iterative medicinal chemistry, and full characterisation turn a promising scaffold into a selective, cell-active probe.
Chemical biology
We use those molecules to interrogate the SWI/SNF and Polycomb complexes — BRD7, PBRM1, CBX2 — and ask what each subunit actually does as prostate cancer progresses. Chemical probes let us test function directly in cells rather than infer it.
Drug development
We screen, triage, and optimise: biochemical and cellular assays measure potency and selectivity, and computational docking guides the next round. The aim is chemical matter good enough to become a therapeutic starting point.
See a project you'd like to join?
Tell us which area interests you — we match students to projects, not the other way around.